You should be fine with Chrome. The first thing to do is make sure your Flash player is up to date (get.adobe.com/flashplayer/). Hopefully it'll go smoothly tonight!
From TRI about tonight's show, 5:30 PT/8:30 ET:
Tonight. Weir Here. Gonna Talk About Some Gear. Bob will be joined by Mike McGinn & AJ Santella.
Submit your questions live or in advance using hashtag #WeirHere.